Aod 9604 Peptide

AOD 9604 is a synthetic 16-amino-acid peptide modeled on the 176-191 region at the C-terminus of human growth hormone (hGH). It is studied in the laboratory as a lipolytic fragment, meaning research focuses on how it influences the breakdown of stored fat without the broader growth-signaling effects of the full hGH molecule. Every AOD 9604 vial supplied here is intended strictly for in-vitro and laboratory research, not for human or animal use.

Peptides Please ships research compounds to laboratories and qualified buyers across the USA and Canada, and each batch is third-party tested to ≥99% purity with a certificate of analysis (COA) available on request. Use the sections below to understand what AOD 9604 is, its regulatory status, and how it is prepared for research handling.

What Is AOD 9604?

AOD 9604 (sometimes written AOD-9604) is a modified fragment of amino acids 176-191 from the C-terminal region of human growth hormone, with an added tyrosine residue to stabilize the sequence. It has a molecular weight of roughly 1,817 g/mol. In published research it is described as retaining the fat-metabolizing signal of hGH while, in study models, not raising blood glucose or IGF-1 the way full growth hormone does. The original characterization work is indexed on PubMed.

AOD 9604 Mechanism Studied in Research

Laboratory research into AOD 9604 centers on lipolysis, the enzymatic breakdown of stored triglycerides into free fatty acids. Across the literature, three mechanisms are most often examined:

• Stimulated lipolysis: study models show mobilization and breakdown of stored fat into free fatty acids.
• Beta-adrenergic signaling: research reports increased beta-adrenergic receptor expression in adipose tissue, raising lipolytic sensitivity.
• Reduced lipogenesis: the fragment is studied for its apparent suppression of new fat formation.

A peer-reviewed overview of this pharmacology is available via PubMed Central.

AOD 9604 FDA Approval Status

AOD 9604 is not FDA-approved. It is not authorized as a drug, dietary supplement, food, or cosmetic, and it is not cleared for human or veterinary use. Here is the regulatory history in brief:

• Clinical development: The compound was advanced by Metabolic Pharmaceuticals through a series of human clinical trials, reported across roughly six Phase I/II studies involving more than 900 participants, with a consistently clean safety profile.
• Why it stalled: Development was halted around 2007 after the oral formulation failed to meet its primary efficacy endpoint for statistically significant weight loss in its largest Phase II trial.
• Current classification: Because the manufacturer ended development before completing a New Drug Application (NDA), the FDA treats it as an unapproved new drug. Detail on the trial record is indexed via PubMed Central.

For research buyers this is the key point: AOD 9604 is supplied here as a research chemical only. Peptides Please is a research chemical supplier, not a compounding pharmacy or a 503A/503B outsourcing facility.

AOD 9604 Reconstitution for Laboratory Handling

AOD 9604 ships as a lyophilized (freeze-dried) powder and must be reconstituted before it can be handled in solution. It is a relatively hydrophobic fragment, so careful preparation matters for a clear, stable working solution. General laboratory practice reported across the research literature:

• Diluent: Sterile reconstitution water (bacteriostatic water) is standard; a dilute 0.1-1% acetic acid solution is sometimes used to help a stubborn fragment dissolve fully. Avoid strongly basic solutions and reducing agents.
• Equilibrate first: Let the sealed vial and diluent reach room temperature (about 10-30 minutes) to reduce the chance of gelling or clouding.
• Add slowly: Inject the diluent down the inner wall of the vial rather than straight onto the powder cake to limit foaming and shear.
• Mix gently: Swirl, do not shake or vortex. Full dissolution typically takes a minute up to several minutes.
• Example volume: To prepare a 1 mg/mL stock from a 5 mg vial, add 5 mL of diluent; adjust the diluent volume to reach the target concentration your protocol calls for.
• Storage: Refrigerate at 2-8°C for short-term use (about 24-48 hours) and hold longer-term aliquots at -20°C, away from light. Avoid repeated freeze-thaw cycles, which degrade the peptide.

Reconstitution is a laboratory preparation step only and does not imply any human or animal application.

Quality and Third-Party Testing

Reconstitution quality depends on the starting material. Impure or poorly freeze-dried peptide can cloud, gel, or introduce error into research data. Every AOD 9604 batch from Peptides Please is manufactured in certified facilities and verified by independent third-party laboratories at ≥99% purity, with a COA available so you can confirm identity and purity before you begin.

If AOD 9604 is temporarily out of stock, you can explore related metabolic research peptides below while restock is pending, or browse the full catalogue.

Browse All Research Peptides   Explore Metabolic Research Peptides

Related Research Peptides

Researchers studying metabolic and body-composition pathways often work alongside AOD 9604 with other compounds in the same area:

• Mazdutide — a GLP-1/glucagon dual-agonist studied in metabolic research.
• Cagrilintide — an amylin analog studied for appetite and body-weight pathways.
• 5-Amino-1MQ — a small molecule studied for NNMT inhibition and fat metabolism.

Frequently Asked Questions

What exactly is AOD 9604?

It is a synthetic 16-amino-acid fragment of human growth hormone (residues 176-191 plus a tyrosine), studied in the laboratory for its effect on fat breakdown (lipolysis).

Is AOD 9604 FDA approved?

No. AOD 9604 is not FDA-approved for any use. It is supplied strictly as a research chemical and is not for human or animal consumption.

Why is AOD 9604 not FDA approved?

Its developer, Metabolic Pharmaceuticals, halted development around 2007 after the compound failed to meet the primary weight-loss endpoint in its largest Phase II trial, so no New Drug Application was completed.

What is used to reconstitute AOD 9604?

In laboratory settings it is reconstituted with sterile bacteriostatic water, sometimes with a dilute acetic acid solution to aid dissolution, then stored cold and protected from light.

How pure is the AOD 9604 sold here?

Every batch is independently third-party tested to ≥99% purity, with a certificate of analysis available on request.

Buy AOD 9604 Peptide for Research

Peptides Please supplies third-party-tested AOD 9604 for laboratory research, shipped across the USA and Canada with a COA available on request. View the vials above to order, or if restock is pending, browse all research peptides in the meantime.